منابع مشابه
Proliferating cardiac microtubules.
IDENTIFYING THE MECHANISMS underlying the transition from adaptive cardiac hypertrophy to maladaptive cardiac failure has long been a central goal of basic and clinical cardiovascular science. Such studies at the level of the cardiocyte have focused largely on the cardiac motor, i.e., the myofilament, as well as the fuel for that motor, i.e., the mitochondrion, and the governor of its activity,...
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Microtubules, the active filaments with tubular shapes, play important roles in a wide range of cellular functions, including structural supports, mitosis, cytokinesis, and vesicular transport, which are essential for the growth and division of eukaryotic cells. Finding properties of microtubules is one of the main concerns of scientists. This work helps to obtain mechanical properties of m...
متن کاملMicrotubules modulate cardiomyocyte beta-adrenergic response in cardiac hypertrophy.
The role of microtubules in modulating cardiomyocyte beta-adrenergic response was investigated in rats with cardiac hypertrophy. Male Sprague-Dawley rats underwent stenosis of the abdominal aorta (hypertensive, HT) or sham operation (normotensive, NT). Echocardiography and isolated left ventricular cardiomyocyte dimensions demonstrated cardiac hypertrophy in the HT rats after 30 wk. Cardiomyocy...
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Cardiac function relies on the ability of the myocytes to develop force and shorten, as well as on the geometry of the heart, which translates shortening into stroke volume and force per cell into pressure in the lumen of the chambers. The requirements of circulation are met by adjustment of heart rate and power output by the myocytes. The heart adapts acutely to a hemodynamic load by increasin...
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Wnt ؉ BMP ؍ stem cell tem cell fate is determined by growth factors. But on page 309, Kléber et al. show that the right combination of growth factors can also keep cells from committing to a differentiated fate. Neural crest stem cells (NCSCs), they find, are maintained by the dual punch of Wnt and BMP. NCSCs have the potential to become many different cell types. For example, Wnt exposure of...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2009
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00517.2009